| No. |
Title |
Date |
Link |
| 1997 |
| 1 |
Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 97-3981) |
03-01-1997 |
Link |
| 1999 |
| 1 |
The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4494) |
03-11-1999 |
Link |
| 2 |
Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4495) |
06-01-1999 |
Link |
| 3 |
Evaluation of the Validation Status of Toxicological Methods: General Guidelines for Submissions to ICCVAM (NIH Publication 99-4496 - Superseded by NIH Publication 03-4508) |
10-01-1999 |
Link |
| 2000 |
| 1 |
Background Review Document: Frog Embryo Teratogenesis Assay -- Xenopus (FETAX) |
03-10-2000 |
Link |
| 2 |
ICCVAM Authorization Act of 2000 (Public Law 106-545) |
12-19-2000 |
Link |
| 2001 |
| 1 |
ICCVAM Immunotoxicity Working Group Recommended Protocol for the Murine Local Lymph Node Assay (LLNA): Testing of Chemicals for Contact Sensitizing (Allergic Contact Dermatitis) Potential |
01-12-2001 |
Link |
| 2 |
ICCVAM Procedures for Test Methods That Have Been Endorsed by ECVAM |
04-23-2001 |
Link |
| 3 |
ICCVAM Recommendations on In Vitro Methods for Assessing Acute Systemic Toxicity (Appendix I of 2001 Workshop Report, NIH Publication No. 01-4499) |
08-01-2001 |
Link |
| 4 |
Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity: Based on Recommendations from an International Workshop Organized by ICCVAM and NICEATM |
08-01-2001 |
Link |
| 5 |
Background Review Document - EPISKIN(TM), EpiDerm(TM)(EPI-200), and Rat Skin Transcutaneous Electrical Resistance (TER) - In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals |
08-12-2001 |
Link |
| 6 |
Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Results of an International Workshop Organized by ICCVAM and NICEATM (NIH Publication 01-4499) |
08-17-2001 |
Link |
| 7 |
ICCVAM Recommended Reporting Template: NRU Test |
08-28-2001 |
Link |
| 8 |
The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH Publication No. 02-4501): Volume 1 |
11-12-2001 |
Link |
| 9 |
The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH Publication No. 02-4501): Volume 2 |
11-12-2001 |
Link |
| 10 |
The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH Publication No. 02-4501) (Table of Contents in HTML) |
11-30-2001 |
Link |
| 11 |
Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) |
12-19-2001 |
Link |
| 2002 |
| 1 |
ICCVAM Evaluation of EPISKIN(TM), EpiDerm(TM), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals (NIH Publication No. 02-4502) |
07-22-2002 |
Link |
| 2 |
Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Binding Assays (NIH Publication No. 03-4506) |
09-01-2002 |
Link |
| 3 |
Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Binding Assays (NIH Publication No. 03-4504) |
09-01-2002 |
Link |
| 4 |
Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays |
09-01-2002 |
Link |
| 5 |
Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4505) |
09-01-2002 |
Link |
| 6 |
Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4507) |
09-01-2002 |
Link |
| 2003 |
| 1 |
ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays (NIH Publication No. 03-4503) |
05-01-2003 |
Link |
| 2 |
ICCVAM Guidelines for the Nomination and Submission of New, Revised and Alternative Test Methods (NIH Publication No. 03-4508) |
09-01-2003 |
Link |
| 3 |
ICCVAM Biennial Progress Report 2002-2003 (NIH Publication No. 04-4509) |
12-19-2003 |
Link |
| 2004 |
| 1 |
Interagency Coordinating Committee on the Validation of Alternative Methods: Mission, Vision and Strategic Priorities |
02-11-2004 |
Link |
| 2 |
ICCVAM Review of the In Vivo Rabbit Dermal Corrosivity Test |
02-20-2004 |
Link |
| 3 |
Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion (NIH Publication No. 04-4510) |
05-10-2004 |
Link |
| 2005 |
| 1 |
NICEATM Draft Technical Summary: Reduction of the Number of Animals Required for Ocular Irritancy Testing: A Brief Review of the Literature |
01-04-2005 |
Link |
| 2 |
NICEATM Draft Report: Interim Analysis of the Estimated Potential Underclassification Rates of the Current Rabbit Test for Detecting Ocular Corrosives and Severe Irritants |
01-06-2005 |
Link |
| 3 |
Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants |
03-12-2005 |
Link |
| 4 |
Addendum to the In Vitro Ocular Toxicity Draft Background Review Document - Correction to Addendum Table IV-8 |
08-17-2005 |
Link |
| 5 |
Draft Report: Analysis of the Estimated Underclassification and Overclassification Likelihoods of the Current In Vivo Rabbit Eye Test for Hazard Classification |
11-04-2005 |
Link |
| 6 |
Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants - ADDENDUM |
11-12-2005 |
Link |
| 2006 |
| 1 |
Background Review Document: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH Publication No. 06-4512: Volume 2 of 2) |
03-12-2006 |
Link |
| 2 |
Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Hen's Egg Test - Chrorioallantoic Membrane (Het-CAM) Test Method (NIH Publication No. 06-4515) |
03-12-2006 |
Link |
| 3 |
Background Review Document: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH Publication No. 06-4512: Volume 1 of 2) |
03-12-2006 |
Link |
| 4 |
Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method (NIH Publication No. 06-4513) |
03-12-2006 |
Link |
| 5 |
Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Rabbit Eye (IRE) Test Method (NIH Publication No. 06-4514) |
03-12-2006 |
Link |
| 6 |
Peer Review Panel Report: The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing |
06-01-2006 |
Link |
| 7 |
Finalized Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors |
09-28-2006 |
Link |
| 8 |
NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity) |
10-16-2006 |
Link |
| 9 |
Biennial Progress Report 2004-2005 - Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 06-4516) |
10-24-2006 |
Link |
| 10 |
ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests (NIH Publication No. 07-4519) |
11-01-2006 |
Link |
| 11 |
Background Review Document: In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity (NIH Publication No. 07-4518) |
11-01-2006 |
Link |
| 12 |
ICCVAM Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives (NIH Publication No. 07-4517) |
11-01-2006 |
Link |
| 2007 |
| 1 |
Independent Peer Review Panel Report: Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products |
04-30-2007 |
Link |
| 2008 |
| 1 |
The NICEATM-ICCVAM Five-Year Plan (2008-2012) (NIH Publication No. 08-6410) |
02-05-2008 |
Link |
| 2 |
Report on the ICCVAM-NICEATM/ECVAM Scientific Workshop on Alternative Methods to Refine, Reduce or Replace the Mouse LD50 Assay for Botulinum Toxin Testing (NIH Publication No. 08-6416) |
03-28-2008 |
Link |
| 3 |
ICCVAM Test Method Evaluation Report: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6392) |
05-01-2008 |
Link |
| 4 |
ICCVAM Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6391) |
05-01-2008 |
Link |
| 5 |
Independent Scientific Peer Review Panel Report - Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products |
05-20-2008 |
Link |
| 6 |
Biennial Progress Report: Interagency Coordinating Committee on the Validation of Alternative Methods - 2006-2007 (NIH Publication No. 08-6529) |
10-23-2008 |
Link |
| 2009 |
| 1 |
Recommended Performance Standards: Murine Local Lymph Node Assay (NIH Publication No. 09-7357) |
01-01-2009 |
Link |
| 2 |
Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations |
03-01-2009 |
Link |
| 3 |
ICCVAM Test Method Evaluation Report - The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 09-6439) |
03-01-2009 |
Link |
| 4 |
Independent Scientific Peer Review Panel Report - Updated Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products |
06-01-2009 |
Link |
| 5 |
Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing Methods and Approaches |
07-13-2009 |
Link |
| 2010 |
| 1 |
ICCVAM 2008-2009 Biennial Report (NIH Publication No. 10-7612) |
06-10-2010 |
Link |
| 2 |
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7552) |
06-29-2010 |
Link |
| 3 |
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7551) |
06-29-2010 |
Link |
| 4 |
ICCVAM Test Method Evaluation Report on Using the Murine Local Lymph Node Assay for Testing Pesticide Formulations, Metals, Substances in Aqueous Solutions, and Other Products (NIH Publication No. 10-7512) |
06-29-2010 |
Link |
| 5 |
ICCVAM Test Method Evaluation Report on a Proposed In Vitro Testing Strategy for U.S. Environmental Protection Agency Ocular Hazard Classification and Labeling of Antimicrobial Cleaning Products (NIH Publication No. 10-7513) |
09-13-2010 |
Link |
| 6 |
ICCVAM Test Method Evaluation Report: Recommendations for Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints to Avoid or Minimize Pain and Distress in Ocular Safety Testing (NIH Publication No. 10-7514) |
09-13-2010 |
Link |
| 7 |
ICCVAM Test Method Evaluation Report: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products (NIH Publication No. 10-7553) |
09-13-2010 |
Link |
| 8 |
ICCVAM Test Method Evaluation Report: Recommendation to Discontinue Use of the Low Volume Eye Test for Ocular Safety Testing (NIH Publication No. 10-7515) |
09-13-2010 |
Link |
| 2011 |
| 1 |
Independent Scientific Peer Review Panel Report: Evaluation of the LUMI-CELL ER® (BG1Luc ER TA) Test Method |
05-01-2011 |
Link |
| 2 |
ICCVAM Test Method Evaluation Report: Usefulness and Limitations of the Murine Local Lymph Node Assay for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans (NIH Publication No. 11-7709) |
06-30-2011 |
Link |
| 2012 |
| 1 |
ICCVAM Test Method Evaluation Report - The LUMI-CELL® ER (BG1Luc ER TA) Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals |
02-01-2012 |
Link |
| 2 |
Informational Brochure: "Nominations and Submissions to ICCVAM: A Guide for Test Method Developers and Sponsors" |
03-06-2012 |
Link |
| 3 |
Informational Brochure: "NICEATM-ICCVAM: Advancing Public Health and Animal Welfare" |
03-06-2012 |
Link |
